{"id":290,"date":"2023-05-30T12:00:40","date_gmt":"2023-05-30T12:00:40","guid":{"rendered":"https:\/\/domeagency.ro\/dhrrh\/?p=290"},"modified":"2023-10-31T17:07:12","modified_gmt":"2023-10-31T17:07:12","slug":"philadelphia-chromosome-positive-de-novo-aml-or-blast-phase-cml","status":"publish","type":"post","link":"https:\/\/domeagency.ro\/dhrrh\/philadelphia-chromosome-positive-de-novo-aml-or-blast-phase-cml\/","title":{"rendered":"Philadelphia chromosome positive de novo AML or blast phase CML?"},"content":{"rendered":"

[et_pb_section fb_built=”1″ specialty=”on” custom_padding_last_edited=”off|desktop” _builder_version=”4.23″ _module_preset=”default” custom_padding_phone=”40px||||false|false” locked=”off” global_colors_info=”{}”][et_pb_column type=”2_3″ specialty_columns=”2″ _builder_version=”4.16″ custom_padding=”|||” global_colors_info=”{}” custom_padding__hover=”|||”][et_pb_row_inner custom_padding_last_edited=”on|phone” _builder_version=”4.23″ _module_preset=”default” custom_padding=”||||false|false” custom_padding_tablet=”||||false|false” custom_padding_phone=”||||false|false” global_colors_info=”{}”][et_pb_column_inner saved_specialty_column_type=”2_3″ _builder_version=”4.23″ _module_preset=”default” global_colors_info=”{}”][et_pb_post_title author=”off” date_format=”M, Y” comments=”off” featured_image=”off” _builder_version=”4.23″ _module_preset=”default” title_line_height=”1.1em” title_font_size_tablet=”” title_font_size_phone=”24px” title_font_size_last_edited=”on|phone” global_colors_info=”{}”][\/et_pb_post_title][et_pb_text _builder_version=”4.23″ _module_preset=”default” custom_margin=”||||false|false” custom_padding=”||20px||false|false” hover_enabled=”0″ border_width_top=”1px” border_color_top=”#d8d8d8″ border_width_bottom=”1px” border_color_bottom=”#d8d8d8″ global_colors_info=”{}” sticky_enabled=”0″]<\/p>\n

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Dan-Sebastian SOARE, Georgiana Elena ENE, Daniela DIACONESCU, Delia SOARE, Cristina ENACHE, Cristina MAMBET, Ion DUMITRU, Madalina CIRNU, Ana-Maria VLADAREANU, Eugen RADU, Horia BUMBEA<\/em><\/p>\n

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The BCR::ABL1 translocation and the accompanying Philadelphia chromosome represents the first mutation which defined a disease, chronic myeloid leukemia. It also represents the first druggable target for which a specific compound was developed and accepted in current clinic practice, imatinib. Despite these, there are still areas in which the diagnosis and the best treatment sequence still needs investigation. One such context is the diagnosis and management of BCR::ABL1 positive myeloid neoplasms with \u226520% blasts, more specifically the differentiation between myeloid blast phase chronic myeloid leukemia and BCR::ABL1 positive acute myeloid leukemia. In this paper we present our recent experience with a BCR::ABL1 positive myeloid neoplasms with \u226520% blasts.<\/p>\n

https:\/\/doi.org\/10.59854\/dhrrh.2023.1.1.25<\/a><\/p>\n<\/div>\n<\/div>\n

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ISSN-online<\/strong>\u00a02972-242X<\/p>\n

ISSN-L\u00a0<\/strong>2972-242X<\/p>\n

ISSN-print<\/strong>\u00a03008-220X<\/p>\n

[\/et_pb_text][et_pb_image src=”https:\/\/domeagency.ro\/dhrrh\/wp-content\/uploads\/2023\/10\/cc.jpg” title_text=”cc” _builder_version=”4.23″ _module_preset=”default” global_colors_info=”{}”][\/et_pb_image][et_pb_image src=”https:\/\/domeagency.ro\/dhrrh\/wp-content\/uploads\/2023\/10\/srh.png” title_text=”srh” url=”https:\/\/srh.org.ro\/” url_new_window=”on” _builder_version=”4.23″ _module_preset=”default” custom_padding=”|25px||25px|false|true” global_colors_info=”{}”][\/et_pb_image][\/et_pb_column][\/et_pb_section]<\/p>\n","protected":false},"excerpt":{"rendered":"

Dan-Sebastian SOARE, Georgiana Elena ENE, Daniela DIACONESCU, Delia SOARE, Cristina ENACHE, Cristina MAMBET, Ion DUMITRU, Madalina CIRNU, Ana-Maria VLADAREANU, Eugen RADU, Horia BUMBEA   The BCR::ABL1 translocation and the accompanying Philadelphia chromosome represents the first mutation which defined a disease, chronic myeloid leukemia. It also represents the first druggable target for which a specific compound […]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_et_pb_use_builder":"on","_et_pb_old_content":"","_et_gb_content_width":"","footnotes":""},"categories":[14],"tags":[],"class_list":["post-290","post","type-post","status-publish","format-standard","hentry","category-2023-vol-1-issue-1"],"_links":{"self":[{"href":"https:\/\/domeagency.ro\/dhrrh\/wp-json\/wp\/v2\/posts\/290","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/domeagency.ro\/dhrrh\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/domeagency.ro\/dhrrh\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/domeagency.ro\/dhrrh\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/domeagency.ro\/dhrrh\/wp-json\/wp\/v2\/comments?post=290"}],"version-history":[{"count":3,"href":"https:\/\/domeagency.ro\/dhrrh\/wp-json\/wp\/v2\/posts\/290\/revisions"}],"predecessor-version":[{"id":293,"href":"https:\/\/domeagency.ro\/dhrrh\/wp-json\/wp\/v2\/posts\/290\/revisions\/293"}],"wp:attachment":[{"href":"https:\/\/domeagency.ro\/dhrrh\/wp-json\/wp\/v2\/media?parent=290"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/domeagency.ro\/dhrrh\/wp-json\/wp\/v2\/categories?post=290"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/domeagency.ro\/dhrrh\/wp-json\/wp\/v2\/tags?post=290"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}