{"id":280,"date":"2023-05-30T12:00:03","date_gmt":"2023-05-30T12:00:03","guid":{"rendered":"https:\/\/domeagency.ro\/dhrrh\/?p=280"},"modified":"2023-10-31T17:00:46","modified_gmt":"2023-10-31T17:00:46","slug":"myelomatous-meningitis-a-diagnostic-and-therapeutic-challenge","status":"publish","type":"post","link":"https:\/\/domeagency.ro\/dhrrh\/myelomatous-meningitis-a-diagnostic-and-therapeutic-challenge\/","title":{"rendered":"Myelomatous Meningitis – a diagnostic and therapeutic challenge"},"content":{"rendered":"

[et_pb_section fb_built=”1″ specialty=”on” custom_padding_last_edited=”off|desktop” _builder_version=”4.23″ _module_preset=”default” custom_padding_phone=”40px||||false|false” locked=”off” global_colors_info=”{}”][et_pb_column type=”2_3″ specialty_columns=”2″ _builder_version=”4.16″ custom_padding=”|||” global_colors_info=”{}” custom_padding__hover=”|||”][et_pb_row_inner custom_padding_last_edited=”on|phone” _builder_version=”4.23″ _module_preset=”default” custom_padding=”||||false|false” custom_padding_tablet=”||||false|false” custom_padding_phone=”||||false|false” global_colors_info=”{}”][et_pb_column_inner saved_specialty_column_type=”2_3″ _builder_version=”4.23″ _module_preset=”default” global_colors_info=”{}”][et_pb_post_title author=”off” date_format=”M, Y” comments=”off” featured_image=”off” _builder_version=”4.23″ _module_preset=”default” title_line_height=”1.1em” title_font_size_tablet=”” title_font_size_phone=”24px” title_font_size_last_edited=”on|phone” global_colors_info=”{}”][\/et_pb_post_title][et_pb_text _builder_version=”4.23″ _module_preset=”default” custom_margin=”||||false|false” custom_padding=”||20px||false|false” hover_enabled=”0″ border_width_top=”1px” border_color_top=”#d8d8d8″ border_width_bottom=”1px” border_color_bottom=”#d8d8d8″ global_colors_info=”{}” sticky_enabled=”0″]<\/p>\n

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Sinziana BARBU, Ruxandra IRIMIA, Popescu MONICA, Diana PREDA, Andreea JERCAN, Daniel CORIU, Sorina BADELITA<\/em><\/p>\n

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Multiple myeloma is a malignant disease, which consists of the clonal proliferation of plasma cells that will lead to the accumulation of a monoclonal protein in the serum and\/or urine, with organic damage. Extramedullary involvement is found in approximately 5% of cases of myeloma. Multiple myeloma with determination in the central nervous system is extremely rare and is associated with a bad prognosis. A targeted treatment scheme for this complication is not described, but the therapeutic approach should follow the same steps as in the case of other lymphoproliferative diseases with neurological involvement ( association of intrathecal chemotherapy applications – cytarabine and methotrexate, with systemic treatment and depending on the response local radiotherapy should be performed). The occurrence of extramedullary disease in the evolution of multiple myeloma is a complication associated with a poor prognosis.<\/p>\n

https:\/\/doi.org\/10.59854\/dhrrh.2023.1.1.13<\/a><\/p>\n<\/div>\n<\/div>\n

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ISSN-online<\/strong>\u00a02972-242X<\/p>\n

ISSN-L\u00a0<\/strong>2972-242X<\/p>\n

ISSN-print<\/strong>\u00a03008-220X<\/p>\n

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Sinziana BARBU, Ruxandra IRIMIA, Popescu MONICA, Diana PREDA, Andreea JERCAN, Daniel CORIU, Sorina BADELITA   Multiple myeloma is a malignant disease, which consists of the clonal proliferation of plasma cells that will lead to the accumulation of a monoclonal protein in the serum and\/or urine, with organic damage. Extramedullary involvement is found in approximately 5% […]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_et_pb_use_builder":"on","_et_pb_old_content":"","_et_gb_content_width":"","footnotes":""},"categories":[14],"tags":[],"class_list":["post-280","post","type-post","status-publish","format-standard","hentry","category-2023-vol-1-issue-1"],"_links":{"self":[{"href":"https:\/\/domeagency.ro\/dhrrh\/wp-json\/wp\/v2\/posts\/280","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/domeagency.ro\/dhrrh\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/domeagency.ro\/dhrrh\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/domeagency.ro\/dhrrh\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/domeagency.ro\/dhrrh\/wp-json\/wp\/v2\/comments?post=280"}],"version-history":[{"count":3,"href":"https:\/\/domeagency.ro\/dhrrh\/wp-json\/wp\/v2\/posts\/280\/revisions"}],"predecessor-version":[{"id":283,"href":"https:\/\/domeagency.ro\/dhrrh\/wp-json\/wp\/v2\/posts\/280\/revisions\/283"}],"wp:attachment":[{"href":"https:\/\/domeagency.ro\/dhrrh\/wp-json\/wp\/v2\/media?parent=280"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/domeagency.ro\/dhrrh\/wp-json\/wp\/v2\/categories?post=280"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/domeagency.ro\/dhrrh\/wp-json\/wp\/v2\/tags?post=280"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}