{"id":270,"date":"2023-05-30T12:00:51","date_gmt":"2023-05-30T12:00:51","guid":{"rendered":"https:\/\/domeagency.ro\/dhrrh\/?p=270"},"modified":"2023-10-31T16:57:26","modified_gmt":"2023-10-31T16:57:26","slug":"cold-agglutinin-disease-diagnostic-and-therapeutic-challenges-in-the-clinical-setting","status":"publish","type":"post","link":"https:\/\/domeagency.ro\/dhrrh\/cold-agglutinin-disease-diagnostic-and-therapeutic-challenges-in-the-clinical-setting\/","title":{"rendered":"Cold Agglutinin Disease \u2013 Diagnostic and Therapeutic Challenges in the Clinical Setting"},"content":{"rendered":"

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Carmen SAGUNA, Alexandra Oana ENACHE, Maria BUBULETE, Mariana RACILA, Andrei COLITA, Nicoleta Mariana BERBEC, Virginia MARIN, <\/em>Elena BALAN, Raluca Mihaela MANOLACHE, Doina BARBU, Silvana ANGELESCU, Oana STANCA, Anca Roxana LUPU<\/em><\/p>\n

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Cold agglutinin disease (CAD) is a rare form of autoimmune hemolytic anemia (AIHA), in which IgM specific antibodies cause the agglutination of red blood cells (RBCs) at temperatures < 37\u00b0C and activate the classical pathway of complement leading to extravascular hemolysis, C3b-coated RBCs are phagocytosed by the macrophages of the reticuloendothelial system (predominantly in the liver). Up to date there are two clinical-pathologic entities recognized as distinct with different therapeutic implications: cold agglutinin disease and cold agglutinin syndrome (CAS). Primary CAD is recognised as clonal B-cell lymphoproliferative disorder of the bone marrow, clinical and imagistic evidence of associated malignancy. CAS arises in the setting of an underlying disorder such as infection, autoimmune disease or malignancy (non-Hodgkin lymphoma or other malignant process). The diagnosis of CAD is often delayed due to the unpredictable clinical course. In spite of the current therapeutic options which are directed at the pathogenic B cells or the complement system, the low response rates and frequent relapses lead to challenges regarding the management of this disease.<\/p>\n

https:\/\/doi.org\/10.59854\/dhrrh.2023.1.1.7<\/a><\/p>\n<\/div>\n<\/div>\n

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ISSN-online<\/strong>\u00a02972-242X<\/p>\n

ISSN-L\u00a0<\/strong>2972-242X<\/p>\n

ISSN-print<\/strong>\u00a03008-220X<\/p>\n

[\/et_pb_text][et_pb_image src=”https:\/\/domeagency.ro\/dhrrh\/wp-content\/uploads\/2023\/10\/cc.jpg” title_text=”cc” _builder_version=”4.23″ _module_preset=”default” global_colors_info=”{}”][\/et_pb_image][et_pb_image src=”https:\/\/domeagency.ro\/dhrrh\/wp-content\/uploads\/2023\/10\/srh.png” title_text=”srh” url=”https:\/\/srh.org.ro\/” url_new_window=”on” _builder_version=”4.23″ _module_preset=”default” custom_padding=”|25px||25px|false|true” global_colors_info=”{}”][\/et_pb_image][\/et_pb_column][\/et_pb_section]<\/p>\n","protected":false},"excerpt":{"rendered":"

Carmen SAGUNA, Alexandra Oana ENACHE, Maria BUBULETE, Mariana RACILA, Andrei COLITA, Nicoleta Mariana BERBEC, Virginia MARIN, Elena BALAN, Raluca Mihaela MANOLACHE, Doina BARBU, Silvana ANGELESCU, Oana STANCA, Anca Roxana LUPU   Cold agglutinin disease (CAD) is a rare form of autoimmune hemolytic anemia (AIHA), in which IgM specific antibodies cause the agglutination of red blood […]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_et_pb_use_builder":"on","_et_pb_old_content":"","_et_gb_content_width":"","footnotes":""},"categories":[14],"tags":[],"class_list":["post-270","post","type-post","status-publish","format-standard","hentry","category-2023-vol-1-issue-1"],"_links":{"self":[{"href":"https:\/\/domeagency.ro\/dhrrh\/wp-json\/wp\/v2\/posts\/270","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/domeagency.ro\/dhrrh\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/domeagency.ro\/dhrrh\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/domeagency.ro\/dhrrh\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/domeagency.ro\/dhrrh\/wp-json\/wp\/v2\/comments?post=270"}],"version-history":[{"count":3,"href":"https:\/\/domeagency.ro\/dhrrh\/wp-json\/wp\/v2\/posts\/270\/revisions"}],"predecessor-version":[{"id":277,"href":"https:\/\/domeagency.ro\/dhrrh\/wp-json\/wp\/v2\/posts\/270\/revisions\/277"}],"wp:attachment":[{"href":"https:\/\/domeagency.ro\/dhrrh\/wp-json\/wp\/v2\/media?parent=270"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/domeagency.ro\/dhrrh\/wp-json\/wp\/v2\/categories?post=270"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/domeagency.ro\/dhrrh\/wp-json\/wp\/v2\/tags?post=270"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}