{"id":218,"date":"2023-08-30T12:02:21","date_gmt":"2023-08-30T12:02:21","guid":{"rendered":"https:\/\/domeagency.ro\/dhrrh\/?p=218"},"modified":"2023-10-31T16:32:37","modified_gmt":"2023-10-31T16:32:37","slug":"prognostic-significance-of-the-number-of-copy-numbervariations-by-mlpa-technique-in-acute-lymphoblastic-leukemia","status":"publish","type":"post","link":"https:\/\/domeagency.ro\/dhrrh\/prognostic-significance-of-the-number-of-copy-numbervariations-by-mlpa-technique-in-acute-lymphoblastic-leukemia\/","title":{"rendered":"Prognostic Significance of the Number of Copy Numbervariations by Mlpa Technique in Acute Lymphoblastic Leukemia"},"content":{"rendered":"

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Amalia-Andrea TITIEANU, Vlad-Andrei CIANGA, Catalin Doru DANAILA, Mihaiela Loredana DRAGOS, Iuliu IVANOV, Angela Smaranda DASCALESCU<\/em><\/p>\n

Acute lymphoblastic leukemia (ALL) is a hematological malignancy with a higher frequency in children than in adults. Adult ALL is associates with increased morbidity and mortality and a significantly lower survival rate compared to its pediatric counterpart with an average survival of 40% at 5 years. The prognosis of patients with ALL is determined by multiple factors, such as age, tumor syndrome, white blood cell counts, cytogenetic abnormalities, and therapeutic response. The Multiplex Ligation-dependent Probe Amplification technique (MLPA) is used to determine the copy number variations (CNV) of several key genes involved in disease progression and resistance, such as IKAROS family zinc finger 1 (IKZF1), PAX5, ETV6, RB1, BTG1, EBF1, CDKN2A\/2B, CRLF2. In this study, we sought to investigate the relationship between these genetic markers and standard prognostic factors in a small cohort of adult ALL patients with the aim of improving our risk stratification strategies.<\/p>\n

https:\/\/doi.org\/10.59854\/dhrrh.2023.1.2.43<\/a><\/p>\n<\/div>\n

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ISSN-online<\/strong>\u00a02972-242X<\/p>\n

ISSN-L\u00a0<\/strong>2972-242X<\/p>\n

ISSN-print<\/strong>\u00a03008-220X<\/p>\n

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Amalia-Andrea TITIEANU, Vlad-Andrei CIANGA, Catalin Doru DANAILA, Mihaiela Loredana DRAGOS, Iuliu IVANOV, Angela Smaranda DASCALESCU Acute lymphoblastic leukemia (ALL) is a hematological malignancy with a higher frequency in children than in adults. Adult ALL is associates with increased morbidity and mortality and a significantly lower survival rate compared to its pediatric counterpart with an average […]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_et_pb_use_builder":"on","_et_pb_old_content":"","_et_gb_content_width":"","footnotes":""},"categories":[13],"tags":[],"class_list":["post-218","post","type-post","status-publish","format-standard","hentry","category-2023-vol-1-issue-2"],"_links":{"self":[{"href":"https:\/\/domeagency.ro\/dhrrh\/wp-json\/wp\/v2\/posts\/218","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/domeagency.ro\/dhrrh\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/domeagency.ro\/dhrrh\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/domeagency.ro\/dhrrh\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/domeagency.ro\/dhrrh\/wp-json\/wp\/v2\/comments?post=218"}],"version-history":[{"count":9,"href":"https:\/\/domeagency.ro\/dhrrh\/wp-json\/wp\/v2\/posts\/218\/revisions"}],"predecessor-version":[{"id":238,"href":"https:\/\/domeagency.ro\/dhrrh\/wp-json\/wp\/v2\/posts\/218\/revisions\/238"}],"wp:attachment":[{"href":"https:\/\/domeagency.ro\/dhrrh\/wp-json\/wp\/v2\/media?parent=218"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/domeagency.ro\/dhrrh\/wp-json\/wp\/v2\/categories?post=218"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/domeagency.ro\/dhrrh\/wp-json\/wp\/v2\/tags?post=218"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}