{"id":124,"date":"2023-08-30T12:00:25","date_gmt":"2023-08-30T12:00:25","guid":{"rendered":"https:\/\/domeagency.ro\/dhrrh\/?p=124"},"modified":"2023-10-31T16:30:55","modified_gmt":"2023-10-31T16:30:55","slug":"the-importance-of-mir-4328-gene-mutations-in-acute-promyelocytic-leukemia","status":"publish","type":"post","link":"https:\/\/domeagency.ro\/dhrrh\/the-importance-of-mir-4328-gene-mutations-in-acute-promyelocytic-leukemia\/","title":{"rendered":"The importance of MIR-4328 gene mutations in Acute Promyelocytic Leukemia"},"content":{"rendered":"

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Onda-Tabita CALUGARU, Mihaela DRAGOMIR, Silvia APOSTEANU, Cerasela JARDAN, Alina Cristiana MEIROSU, Daniel CORIU<\/em><\/p>\n

Acute Promyelocytic Leukemia (APL) is a hematological emergency. Despite the high remission rate, APL therapy, represented by all-trans-retinoic acid (ATRA) and arsenic trioxide (ATO), can lead to severe adverse effects and death. Considering these facts, there is a need to develop a new effective therapeutic line with reduced cytotoxicity and new biomarkers that are more sensitive for disease onset and progression.<\/p>\n

https:\/\/doi.org\/10.59854\/dhrrh.2023.1.2.37<\/a><\/p>\n<\/div>\n

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<\/a><\/p>\n<\/div>\n

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ISSN-online<\/strong>\u00a02972-242X<\/p>\n

ISSN-L\u00a0<\/strong>2972-242X<\/p>\n

ISSN-print<\/strong>\u00a03008-220X<\/p>\n

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Onda-Tabita CALUGARU, Mihaela DRAGOMIR, Silvia APOSTEANU, Cerasela JARDAN, Alina Cristiana MEIROSU, Daniel CORIU Acute Promyelocytic Leukemia (APL) is a hematological emergency. Despite the high remission rate, APL therapy, represented by all-trans-retinoic acid (ATRA) and arsenic trioxide (ATO), can lead to severe adverse effects and death. Considering these facts, there is a need to develop a […]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_et_pb_use_builder":"on","_et_pb_old_content":"","_et_gb_content_width":"","footnotes":""},"categories":[13],"tags":[],"class_list":["post-124","post","type-post","status-publish","format-standard","hentry","category-2023-vol-1-issue-2"],"_links":{"self":[{"href":"https:\/\/domeagency.ro\/dhrrh\/wp-json\/wp\/v2\/posts\/124","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/domeagency.ro\/dhrrh\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/domeagency.ro\/dhrrh\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/domeagency.ro\/dhrrh\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/domeagency.ro\/dhrrh\/wp-json\/wp\/v2\/comments?post=124"}],"version-history":[{"count":17,"href":"https:\/\/domeagency.ro\/dhrrh\/wp-json\/wp\/v2\/posts\/124\/revisions"}],"predecessor-version":[{"id":236,"href":"https:\/\/domeagency.ro\/dhrrh\/wp-json\/wp\/v2\/posts\/124\/revisions\/236"}],"wp:attachment":[{"href":"https:\/\/domeagency.ro\/dhrrh\/wp-json\/wp\/v2\/media?parent=124"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/domeagency.ro\/dhrrh\/wp-json\/wp\/v2\/categories?post=124"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/domeagency.ro\/dhrrh\/wp-json\/wp\/v2\/tags?post=124"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}